Data analysis of implementability of Pharmacogenomics guided dose modifications in eight African countries
Description
Data for analysis of implementability of Pharmacogenomics in 8 African countries with ML# rated National Regulatory Authorities- based on registered drug formulation/strength availability as of 1 June 2025. These countries include Egypt, Ghana, Nigeria, Rwanda, Senegal, South Africa, Tanzania, and Zimbabwe.
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We assessed the implementability of pharmacogenomic-biomarker guided interventions, based on the availability of registered drug formulations, in eight African countries with a National Regulatory Authority (NRA) recognized at WHO Global Benchmarking Tool Maturity Level 3 (ML3): Egypt, Ghana, Nigeria, Rwanda, South Africa, Senegal, Tanzania and Zimbabwe. For each medicine with an actionable pharmacogenomic biomarker in each of the National Eseential Medicines List (NEML), we downloaded all registered medicine brands along with their formulations and strengths from each countries listed of registered human medicines.(downloaded on 15/07/2025.) Implementability was considered feasible if a registered product's formulation and strength allowed dose adjustments according to PGx guidelines. For instance, if the normal dose of drug X is 100mg daily but a certain phenotype requires 50mg and only a 100mg capsule is available, the recommendation is unimplementable. If, however, a 50mg formulation or an oral suspension is registered in the coutry the recommendation is implementable. This process was applied to each MAPB in each eight ML3 countries. All medicines with a recommendation to use an alternative were assumed to be feasible along with all medicines for intravenous administration in dose modification in this analysis. The dataset generated for this analysis comprising the the medicines names, nature of recommendation (i.e. use alternative drug, dose modification or both), total registers brands, formulations available and the lowest and highest product strengths available, coclusion we derived on implementability of the recommendation and the reason for the assigned conclusion
Institutions
- African Institute of Bio-medical Science and TechnologyHarare, Harare