Evaluation of dry eye severity and ocular surface inflammation in patients with pemphigus and pemphigoid

Description

A total of 22 patients (15 pemphigus and 7 pemphigoids) and 21 non-diseased controls were enrolled in our study. All participants underwent ocular surface evaluation, which included ocular surface disease index (OSDI) test, slit lamp observation, dry eye-related examination, tear multicytokine analysis, and conjunctival impression cytology

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All statistical analyses in this study were performed using GraphPad Prism 8 (GraphPad Software Inc., San Diego, USA) and SPSS 20 (SPSS Inc., Chicago, USA). Independent t-tests were used to analyze the normally distributed data, and these data are presented as the mean ± SD. Median ± quartile spacing and the Mann–Whitney U test were used to analyze the nonnormally distributed data. The Chi-square test or Mann–Whitney U test was used for the comparison of classified data. Correlation analysis was performed using Spearman's test. Differences with P < 0.05 were considered significant.

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