A Review on Probable Lysosomotropic Properties of Sodium Bicarbonate to Restrain Viral Entry of Coronavirus 2 (SARS-CoV-2)

Published: 05-05-2020| Version 1 | DOI: 10.17632/zzzk3fmymf.1
Mudasir Mir,
Sheikh Mansoor,
Abida Bhat


SARS-CoV-2 causing COVID-19 has appeared as an ongoing global public crisis, growing with geometric progression and has caused huge devastation till date majorly because of lack of targeted therapeutic agents like vaccines. The entry of Coronavirus-2 into host cells being acidic pH dependent. Thus, in the current clinical emergency there is a pressing need to look forward for adjunct therapies which could counter the acidic pH, so as to restrain the viral entry and its subsequent reproduction in the host cells. Therefore, the current review attempted to explore the possibility to use sodium bicarbonate as an alternative lysosomotropic agent based on the reported literature owing to its anti-flu properties and widespread use during Spanish pandemic of 1918. The suggestions put forward in the current review article based on the careful use of sodium bicarbonate could probably help to restrain SARS-CoV-2 infection.