Mendeley Data Showcase

This dataset contains the raw biochemical, molecular, data and statistics from an in vivo experimental study evaluating the therapeutic efficacy of terazosin, an alpha-1 adrenergic receptor antagonist, in a surgically induced rat model of endometriosis.

Local Climate Zone classification training areas for São Paulo, Campinas and Santos to be used in LCZ Generator. The polygons were created in 30 March 2026 using Google Earth Pro.

Here, we provide a description of the behavioral response and dataset used for this protocol pipeline. Following the loss of environmental illumination, zebrafish will engage in a circling behavior in an attempt to locate a source of light. On repeated observations of this behavior, zebrafish and other fish species will preferentially circle in a consistent direction, exhibiting a persistent motor bias for either leftward or rightward circling. This behavior is controlled by a subset of approximately 60 neurons in the lateral thalamus referred to as asymmetry maintaining neurons (AMNs). The AMNs are made up of two bilateral clusters that maintain an individual’s motor bias direction. Following the loss of illumination, AMNs will exhibit larger calcium flux in the AMN cluster from the hemisphere contralateral to the individual’s bias. For example, a rightward circling zebrafish will exhibit stronger responses to the loss of illumination from the AMN cluster in the left hemisphere of the brain. This correlation between behavior, neurophysiology, and neuron type provides a powerful system to resolve and evaluate functional imaging data. Moreover, this dataset allows for the application of motion correction, cell segmentation using nuclear localized GCaMP, and ROI segmentation. For the purpose of this protocol, the calcium imaging dataset used to determine this functional thalamic asymmetry will be used as a sample dataset. However, MCA is compatible with a variety of functional imaging techniques and is viable across multiple GEIs, model organisms, and imaging methods such as confocal and multiphoton based functional imaging. This protocol is targeted towards computers and laptops running the Microsoft Windows 11 operating system; however, it is also applicable to Linux and Mac operating systems.

Data from the manuscript "Density-dependent effects of herbivores on juvenile coral survivorship in ex situ nurseries".

Dataset ini berisi 800 ulasan pengguna aplikasi Tokopedia yang diambil dari Google Play Store. Pengambilan data dilakukan pada tanggal 25 Maret 2026 menggunakan library google-play-scraper (Python). Setiap ulasan dilengkapi dengan rating bintang (1-5), jumlah like (thumbsUpCount), tanggal ulasan (at), dan telah dilabeli sentimen menjadi positif (rating 4-5), netral (rating 3), dan negatif (rating 1-2). Dataset ini dapat digunakan untuk analisis sentimen, klasifikasi teks, dan penelitian data mining.

Supporting dataset for the manuscript "Post-Mine Closure Land-Use Optimization: A General Framework Using Markowitz Portfolio Optimization Theory".

The dataset consists of a total of 12 scattered light intensity measurements of InGaN nanowire samples. Each file contains the data from one measurement run. Six of the measurement runs were taken on intact samples ('nd'), whilst the remaining six were carried out on samples exhibiting surface defects in the form of low wire densities and short wire lengths ('d'). The measurements were carried out using the setup described in the citing publication and covered a section of the scattered light sphere comprising 89 x 27 measurement points with a step size of 1° in elevation and azimuth direction. The intensities are captured in auxiliary units, since only the intensity relation between the measurement positions is of interest. The experimental data about the measurement procedure, the laser, the detector etc. can be found in the citing publication.

The purpose of this study was to identify the genomic rearrangements present in a transgenic mouse line (Line 781) that expresses a lacZ reporter gene cassette. Mice hemizygous for the transgene have a mutant phenotype (smaller body size and paws, and craniofacial aberrations), whereas their non-transgenic littermates are phenotypically normal. The transgene inserted near or at a reciprocal translocation (RT) between chromosomes 1 and 2 as determined by fluorescent in situ hybridization (FISH) analysis. Optical genome mapping (OGM) was performed to better identify the genomic rearrangements present in the mutant mouse genome. OGM was performed with ultra-high molecular weight genomic DNA isolated from a mutant female mouse, with an average length of 246.092 kbp. The DNA was labeled with DL-green fluorophores at CTTAAG sites with DLE-1 methyltransferase. Because the target site is palindromic, both DNA strands get labeled. The label density averaged 15.017 labels per 100 kb. The labeled DNA was analyzed on the Bionano Saphyr system to measure the distance between labels (tags) for each single, extremely long strand of genomic DNA (‘molecule’). The resulting data was entered into the de novo assembly pipeline to group the molecules by label pattern similarity in order to create maps, which then were used to construct the mutant genome. The rare variant analysis pipeline was used to compare the assembly against a reference genome (GRCm38.p6). Areas of discrepancy within the mutant genome were identified using the structural variant (SV) caller. It indicated that the RT junction in der2 was separated by extraneous DNA, which happens to be the transgene. Based on target sites for labeling within the transgene sequence, it was estimated that five complete copies of the transgene integrated in a tail-to-head orientation, directly between the breakpoints in der2. The breakpoints in der2 were estimated to be in the vicinity of positions chr2:106,476,853 and chr1:163,466,814. OGM results also estimated the RT junction in der1 occurs near positions chr1:159,566,643 and chr2:108,255,381. Taken together, the data suggest that parts of chromosomes 1 and 2 were deleted during the reorganization of the mutant genome. As well, copy number variant (CNV) analysis was performed for the mutant genome using the Bionano software. The analysis confirmed areas of monosomy within chromosomes 1 and 2, which correspond to gaps of missing sequence in the derivative chromosomes when the SV caller estimated breakpoints are considered in combination. Thus, the RT is unbalanced, with segments of chr1 (3.9 Mbp) and chr2 (1.8 Mbp) missing from the derivative chromosomes. The breakpoints were identified precisely by Sanger sequencing of PCR products that span a junction between chromosomal breakpoints or with the transgene. Thus, it is likely that the phenotype in mutant animals is due to the deletion of a gene or genes within the deleted sequence.

Blood glucose homeostasis relies on coordinated rhythmic activity across pancreatic islets. Glucose triggers islet rhythmicity, but population-level dynamics in pancreases in vivo remain unclear. Using simultaneous multi-islet Ca2+ imaging in mice and tissue, we systematically studied how glycemia fluctuations and intra-islet paracrine signaling collectively shape the islet rhythmicity. In this study, we report that a transition from Hyperglycemia to Euglycemia drove a coordinated shift from Slow to Fast islet Ca2+ oscillations (HESF) in vivo. HESF was conserved in pancreatic tissue slices, but not in dispersed single β cells in vitro, linking the transition to paracrine signaling. Mechanistically, HESF arose from α-cell activation, which is inhibited by δ cells during hyperglycemia. In diabetic mice with unstable glycemia, islets lost HESF both in vivo and in vitro. Semaglutide restored HESF while stabilizing glycemia. These findings reveal how δ and α cells encode glycemic state into islet rhythmicity to support stable blood glucose.