The American Journal of Cardiology

Dataset shows the echocardiographic measurements for 44 patients with takotsubo cardiomyopathy and 60 normal controls. 11 of the takotsubo patients had echocardiography before the ballooning event and 33 had echocardiography afterwards.

The 10 year rates of clinical outcomes in 2240 patients with LMCA disease in the MAIN-COMPARE registry, including 1102 patients who underwent stenting and 1138 who underwent CABG.

This record contains raw data related to the article "Outcomes of Transcatheter Aortic Valve Replacement Patients With Different Transvalvular Flow-gradient Patterns". Low-flow low-gradient (LF-LG) aortic stenosis (AS) may occur with preserved or depressed left ventricular ejection fraction (LVEF). Both situations represent the most challenging subset of patients to manage and generally have a poor prognosis. Few and controversial data exist on the outcomes of these patients compared to normal-flow high-gradient (NF-HG) AS following transcatheter aortic valve replacement (TAVR). We sought to characterize different transvalvular flow-gradient patterns and to examine their prognostic value after TAVR. We enrolled 1208 patients with severe AS and categorized as follow: 976 patients NF-HG (mean aortic pressure gradient, MPG≥40mmHg), 107 paradoxical cLF-LG (pLF-LG, MPG<40mmHg, LVEF≥50%, stroke volume index, SVi<35mL/m2), and 125 cLF-LG (MPG<40mmHg, LVEF<50%, SVi<35mL/m2). When compared with NF-HG and pLF-LG, cLF-LG had a worse symptomatic status (NYHA III-IV 86% vs 62% and 67%, p<0.001), a higher prevalence of eccentric hypertrophy and a higher level of LV global afterload reflected by a higher valvuloarterial impedance. Valvular function after TAVR was excellent over time in all patients. While 30-day mortality (p=0.911) did not differ significantly among groups, cLF-LG had a lower 5-year survival rate (LF-LG 50% vs pLF-LG 62% and NF-HG 68%, p<0.05). cLF-LG was associated with a hazard ratio for mortality of 2.41 (95% CI: 1.65-3.52, p<0.001). In conclusion, TAVR is an effective procedure regardless of transvalvular flow-gradient patterns. However, special care should be given to characterized hemodynamic of AS, as patients with pLF-LG had similar survival rates than patients with NF-HG, whereas cLF-LG is associated with a 2-fold increased risk of mortality at 5-year follow-up.

This record contains raw data related to the article "Etiology and Outcome of Catheter Ablation in Patients With Onset of Atrial Fibrillation <45 Years of Age". Abstract Etiologic factors and long-term outcomes of catheter ablation of atrial fibrillation (AF) in young patients have not been well characterized. This study aimed to analyze the etiologic factors and outcomes of pulmonary vein isolation (PVI) in patients with young-onset AF (young-AF, defined as having first documented episode <45 years). Consecutive patients with young-AF undergoing PVI (n = 197) in 2 academic centers were enrolled and followed for 36.1 ± 24.5 months. A control group of patients with AF onset ≥45 years (n = 554) was included. The most frequent risk factors in young-AF were intensive exercise (25%), moderate-to-heavy alcohol consumption (23%), and familial AF (22%). Compared with patients with AF onset ≥45-year, patients with young-AF were more often men (82% vs 66%, p <0.001), had more frequently paroxysmal AF (81% vs 60%, p <0.001), had less left atrial dilatation (40.9 ± 6.2 mm vs 44.2 ± 7.2 mm, p <0.001), and had lower 4-year recurrence rate after last PVI procedure (22% vs 45%, p <0.001). In young-AF, structural heart disease (SHD) was the only independent predictor of recurrence. Patients with young-AF selected to undergo cryoballoon (CB) ablation were younger (35.0 ± 7.7 vs 36.6 ± 6.7 years, p = 0.035) and had less persistent AF (6% vs 24%, p = 0.004) and coronary artery disease (2% vs 7%, p = 0.02) compared with radiofrequency ablation. After excluding patients with persistent AF and SHD, there was no difference in single procedural success between radiofrequency or CB PVI (27% vs 17%, p = 0.11). In conclusion, patients with young-AF have diverse etiologies and high single and multiprocedural PVI successes. SHD is the only independent predictor of recurrence. In patients with young-AF, there is a selection bias for CB ablation.

Summary-level coronary artery disease (CAD) and ischaemic stroke (IS) GWAS data generated by Genomics plc as presented in: Weale M. et al. Validation of an integrated risk tool, including polygenic risk score, for atherosclerotic cardiovascular disease in multiple ethnicities and ancestries. American Journal of Cardiology (in press). If you have any questions or comments regarding these files, please contact Genomics plc at research@genomicsplc.com NOTES ----------------------------- These analyses were carried out using the full UK Biobank imputation data release (v3b). Analyses were restricted to a subset of UK Biobank, described as “PRS training” in the Supplementary Materials of the published paper. “PRS training” included 187,150 randomly sampled individuals from the White British unrelated (WBU) UK Biobank subset. CAD and IS case phenotypes were defined as described in the “UK Biobank phenotype definitions” section of the paper’s Supplementary Materials, using both prevalent (pre-baseline) and incident (post-baseline) events. All analyses included age-at-assessment, sex, genotyping chip, and 10 principal components as covariates. We used plink2.0 logistic regression. For chromosome X variants males were treated as having 0 or 2 alternative alleles. The results are not adjusted for genomic control. DATA FILE CONTENT DESCRIPTION ----------------------------- cpra: Variant ID in ‘CPRA’ format. Position reflects position in b37. chrom: Chromosome pos: Position in base pairs (b37, 1-based) alt: Alternative allele (effect allele) beta: Effect size (log odds ratio) standard_error: Standard error of beta minus_log10_p: Minus log(base 10) of P-value ref: Reference allele (non-effect allele) ncase: Number of cases ncontrol: Number of controls