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- Data for: Loss of cell-matrix contact increases hypoxia-inducible factor-dependent transcriptional activity in glioma cellssome data files
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- Data for: Reflector of the body photophore in lanternfish is mechanistically tuned to project the biochemical emission in photocytes for counterilluminationX-ray diffraction
- Dataset
- Data for: PTP1B up-regulates EGFR expression by dephosphorylating MYH9 at Y1408 to promote cell migration and invasion in esophageal squamous cell carcinomaThe research data contain the original files generated from LC/MS/MS to detect the proteins which interacted with PTP1B in ESCC cell line KYSE150.
- Dataset
- Data for: Proscillaridin A induces apoptosis and inhibits the metastasis of osteosarcoma in vitro and in vivoProscillaridin A suppressed proliferation, induced apoptosis, and inhibited 143B cell metastasis in vitro and in vivo, and these effects could be mediated by downregulating the expressions of Bcl-xl and MMP2.
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- Data for: Sensation of TRPV1 via 5-hydroxytryptamine Signaling modulates pain hypersensitivity in a 6-hydroxydopamine induced mice model of Parkinson's diseaseAll the behavior test data mentioned in the paper was involved.
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- Data for: Reflector of the body photophore in lanternfish is mechanistically tuned to project the biochemical emission in photocytes for counterilluminationFTIR data
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- Data for: Liraglutide promotes the angiogenic ability of human umbilical vein endothelial cells through the JAK2/STAT3 signaling pathwayresearch data
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- Data for: Jiadifenolide induces expression of cellular communication network factor (CCN) genes, and CCN2 possesses neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cellsJiadifenolide induces expression of cellular communication network factor (CCN) genes, and CCN2 possesses neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells Jiadifenolide has been reported to have neurotrophin-like activity in primary rat cortical neurons, and also possesses neurotrophic effects in neuronal precursor cells derived from human induced pluripotent stem cells (hiPSCs), as we have previously reported. However, the molecular mechanisms by which jiadifenolide exerts its neurotrophic effects in rat and human neurons are unknown. Thus, we aimed to investigate the molecular mechanisms and pathways by which jiadifenolide promotes neurotrophic effects. Here, we found that jiadifenolide activated cellular communication network factor (CCN) signaling pathways by up-regulating mRNA level expression of CCN genes in human neuronal cells. We also found that CCN2 (also known as connective tissue growth factor, CTGF) protein promotes neurotrophic effects through activation of the p44/42 mitogen-activated protein kinase (MAPK) signaling pathway. This is the first discovery which connects neurotrophic effects with CCN signaling.
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- Data for: The Role of PKC and PKD in CXCL12 directed Prostate Cancer Migrationraw data incorporated in powerpoint files
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- Data for: Dynamical phase transition in spike neuronal firing patterns of hippocampal cellsTo determine the dynamical state of the neurons, we have focused on the statistics of the distributions of inter-spike intervals. In particular, we identify two states. The first is the basal state, in which cell spiking follows non-correlated (memory-less) random statistics, usually with a Poisson-like distribution of intervals. The second state is obtained by the activation of the phospholipase C (PLC) signaling cascade with oxotremorine-M (Oxo-M), a M1 receptor agonist, which introduces temporal correlations in the spiking intervals. We interpret these correlations as a shift of the neuronal dynamics towards a critical state. We corroborate that this shift in dynamics is due to a change in the M-channel by applying the specific channel blocker XE991, as well as by blocking the phospholipase C (PLC) with U73122.
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