Journal of Controlled Release
ISSN: 0168-3659
Datasets associated with articles published in Journal of Controlled Release
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- Data for: Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer FACS and Confocal microscopy data
- Data for: Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapyendosome release of siRNA
- Data for: Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapyCD4+ and CD8+staining of tumor section
- Data for: Enzyme Responsiveness Enhances the Specificity and Effectiveness of Intelligent Nanoparticles for the Treatment of B16F10 MelanomaA part of Raw data
- Data for: Photothermal-Reinforced and Glutathione-Triggered in Situ Cascaded Nanocatalytic TherapyTumor microenvironment (TME)-responsive nanoformulations that catalyze a cascade of intracellular redox reactions showed promise for tumor treatment with high specificity and efficiency. In this study, we report Cu2+-doped zeolitic imidazolate frameworks-coated polydopamine nanoparticles (PDA@Cu/ZIF-8 NPs) for glutathione-triggered and photothermal-reinforced sequential catalytic therapy against breast cancer. In the TME, the PDA@Cu/ZIF-8 NPs could initially react with antioxidant glutathione (GSH), inducing GSH depletion and Cu+ generation. Whereafter, the generated Cu+ would catalyze local H2O2 to produce highly toxic hydroxyl radicals (·OH) through an efficient Fenton-like reaction even in weakly acidity. Importantly, the PDA could exert excellent photothermal conversion effect to simultaneously accelerate GSH consumption and improve the Fenton-like reaction for further expanding the intracellular oxidative stress, which innovatively achieves a synergistic photothermal-chemodynamic therapy for highly efficient anticancer treatment.
- Data for: Knockout of hypoxia-inducible factor-1 by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancercellular uptake, tumor deep penetration on tumor spheroids, tumor image, RT-PCR results of expression of HIF-1a, VEGF and CXCR-4.