Journal of Controlled Release

FACS and Confocal microscopy data

A part of Raw data

endosome release of siRNA

CD4+ and CD8+staining of tumor section

Tumor microenvironment (TME)-responsive nanoformulations that catalyze a cascade of intracellular redox reactions showed promise for tumor treatment with high specificity and efficiency. In this study, we report Cu2+-doped zeolitic imidazolate frameworks-coated polydopamine nanoparticles (PDA@Cu/ZIF-8 NPs) for glutathione-triggered and photothermal-reinforced sequential catalytic therapy against breast cancer. In the TME, the PDA@Cu/ZIF-8 NPs could initially react with antioxidant glutathione (GSH), inducing GSH depletion and Cu+ generation. Whereafter, the generated Cu+ would catalyze local H2O2 to produce highly toxic hydroxyl radicals (·OH) through an efficient Fenton-like reaction even in weakly acidity. Importantly, the PDA could exert excellent photothermal conversion effect to simultaneously accelerate GSH consumption and improve the Fenton-like reaction for further expanding the intracellular oxidative stress, which innovatively achieves a synergistic photothermal-chemodynamic therapy for highly efficient anticancer treatment.

cellular uptake, tumor deep penetration on tumor spheroids, tumor image, RT-PCR results of expression of HIF-1a, VEGF and CXCR-4.

This dataset supports the findings reported in the article PEG-PGA Enveloped Octaarginine-Peptide Nanocomplexes: An Oral Peptide Delivery Strategy, published in Journal of Controlled Release (DOI: 10.1016/j.jconrel.2018.03.004). The dataset is provided as an Excel file containing several sheets, each named after the figure in the manuscript to which the dataset corresponds.

This dataset supports the findings reported in the article Bioinspired Orthogonal-Shaped Protein–Biometal Nanocrystals Enable Oral Protein Absorption, published in Journal of Controlled Release (DOI: 10.1016/j.jconrel.2024.11.016). The dataset includes experimental results provided in an Excel file with multiple sheets, each named after the corresponding figure or table in the associated manuscript. For detailed experimental procedures, refer to the Materials and Methods section of the article.