Neuroscience

Self-reported data and all gait initiation COP and kinematic data.

pClamp raw data and Origin files used for Fig. 5

Data corresponding to : Laminin-coated Electrodes Improve Cochlear Implant Function and post-Insertion Neuronal Survival Esperanza Bas1, Mir R Anwar1, Stefania Goncalves1, Christine T Dinh1, Olena R Bracho1, Juan A Chiossone1, Thomas R Van De Water 1 Aims: The benefits of Cochlear implant (CI) technology depend among other factors on the proximity of the electrode array to the spiral ganglion neurons. Laminin, a component of the extracellular matrix, regulates Schwann cell proliferation and survival as well as reorganization of actin fibers within their cytoskeleton, which is necessary for myelination of peripheral axons. In this study we explore the effectiveness of laminin-coated electrodes in promoting neuritic outgrowth from auditory neurons towards the electrode array and the ability to reduce acoustic and electric auditory brainstem response (i.e. aABR and eABR) thresholds. Findings: In vitro: Schwann cells and neurites are attracted towards laminin coated surfaces with longer neuritic processes in laminin-coated dishes compared to uncoated dishes. In vivo: Animals implanted with laminin-coated electrodes experience significant decreases in eABR and aABR thresholds at selected frequencies compared to the results from the uncoated electrodes group. One month post implantation there was a greater number of spiral ganglion neurons and neuritic processes projecting into the scala tympani of animals implanted with laminin-coated electrodes compared to animals with uncoated electrodes. Conclusions: These data suggest that Schwann cells are attracted towards laminin-coated electrodes and promote neuritic outgrowth/ guidance and promote the survival of spiral ganglion neurons following electrode insertion trauma.

pClamp raw data and Origin files used for Fig. 1

pClamp raw data and Origin files used for Fig. 4

Detailed statistical results including F statistics and q value of the data presented in Figures of the paper entitled: Downregulation of aquaporin 9 exacerbates beta-amyloid-induced neurotoxicity in Alzheimer’s disease models in vitro and in vivo.

Description of data files EEG Data files for Fig. 2: • This folder contains data files to generate Fig. 2 Behavioral Data files for Fig. 3: • This folder contains data files to generate Fig. 3 (RMS COP, PL, iTTB). EEG Data files for Figs 4-12: • This folder contains data files to generate Fig. 4 through Fig. 12. • There are 2 folders – one for the TMSSMA group and another for the TMSSHAM group. • Within each subject folder – o .eeg, .vhdr, .vmrk are default files generated by Brain vision software that contains raw data and configurations. o .bvct, .elc are digitized channel files o .txt is some other description for data recording o filenames:  baseline_EO: baseline with eyes open  baseline, 2, 3: baselines with eyes closed  flos: FLOS tasks  trial1, 2, 3: tasks that we performed in order

ABF file

Appendix 1 includes supplementary tables.

Dataset