Psychoneuroendocrinology

This is the data for the article "Relationship between footshock intensity, post-training corticosterone release and contextual fear memory specificity over time". The abstract of this paper states: "Overgeneralized fear has long been implicated in generalized anxiety and post-traumatic stress disorder, however, time-dependent mechanisms underlying memory retrieval are still not completely understood. Previous studies have revealed that stronger fear conditioning training protocols are associated with both increased post-training corticosterone (CORT) levels and fear responses at later retrieval tests. Here we used discriminative contextual fear conditioning (CFC) to investigate the relationship between post-training CORT levels and memory specificity in different retrieval timepoints. Wistar rats were exposed to CFC training with increasing footshock intensities (0.3, 0.6 or 1.0mA) and had their blood collected 30 min afterwards to measure post-training plasma CORT. After 2, 14 or 28 days, rats were tested for memory specificity either in the training or in the novel context. Regression analysis was used to verify linear and non-linear interactions between CORT levels and freezing. Higher footshock intensities increased post-training CORT levels and freezing times during tests in all timepoints. Moreover, stronger trainings elicited faster memory generalization, which was associated with higher CORT levels during memory consolidation. The 0.3mA training maintains memory specificity up to 28 days. Additionally, linear regressions suggest that the shift from specific to generalized memories is underway at 14 days after training. These results are consistent with the hypotheses that stronger training protocols elicit a faster generalization rate, and that this process is associated with increased post-training CORT release." Disclaimer: The IDs of the animals were restarted from 1-1 at each timepoint. The replication animals were not reused from the main experiment. The overlap between ID numbers does not mean that the same animal was trained or tested in more than one parameter.

Cortisol, cardiovascular, and psychological responding to stress in adolescence

Dataset for Lobmaier et al.: Increased sensitivity to social exclusion during the luteal phase: Progesterone as resilience factor buffering against ostracism?

Data and syntax are included here.

SPSS data

Correlational associations between pain, acute traumatic stress, oxytocin and cytokines

Research data files for submitted manuscript to Psychoneuroendocrinology (PNE) entitled - A Peripheral Immune Response to Fear Memory Retrieval Contributes to Fear Memory Maintenance

Dataset beloning to article: Hair cortisol and work stress: importance of workload and stress model (JDCS or ERI)

The study measure theory of mind (ToM) by reading the mind in the eyes test (RMET) in 3 groups of individuals with disorders of sex development (congenital adrenal hyperplasia, complete androgen insensitivity syndrome) and control females and males. it is aimed at separating the effect of prenatal androgen exposure, karyotype and gender assignment by exploiting the unique characteristic of the above DSD conditions. the SPSS file is provided.

Behavioral data collected on the radial arm maze (Experiment 1) and object location memory task (Experiment 2) for adult male rats. Also provided are serum testosterone assays for each experiment, as testosterone levels were manipulated.