Mendeley Data Showcase

These data is a supplementary data for a manuscript entitled " Real-world evidence for the efficacy and safety of risankizumab in moderate-to-severe psoriasis: a systematic review and meta-analysis ". In this study, we showed that risankizumab seemed to be an advantageous treatment option for moderate-to-severe psoriasis with its satisfactory performance in efficacy, safety and drug discontinuation in long term based on real-world evidence. Owing to the current limited number and quality of studies, more long-term and high-quality real-world studies are required for a more comprehensive assessment of risankizumab.

To determine whether in general protected areas (PAs) provide protection from overheating for the lizard populations inhabiting them, we compared the effect of a PA on vegetation cover, and in turn on the microclimate experienced by lizards, at their spatial scale and considering their thermoregulatory behaviors. Using remote sensing and a mechanistic niche model (NicheMapR) we tested whether the Sierra de Huautla Biosphere Reserve (REBIOSH) had higher vegetation cover, cooler microclimates, higher thermal safety margins (TSM), higher foraging duration, and lower metabolic rate for simulated Sceloporus horridus lizards compared to adjacent unprotected areas to the north (NAA) and south (SAA) in 1999—when the reserve was declared—and 2020. The study area is in south-central Mexico and the considered surface is mainly occupied by the seasonally dry tropical forest. Within each polygon, we randomly placed 150 sampling points to which we assign data of our study variables. The sampling points have a spatial resolution of 30 m. We characterized the vegetation cover using the normalized difference vegetation index (NDVI) * 100, that is to say, converted to a percentage. The microclimate was simulated at 3 or 120cm perch height because the latter may be cooler than the former and S. horridus moves along such interval. We calculated the TSM as the voluntary thermal maximum of the species (36.4°C) minus the mean body temperature of the simulated lizard. In the simulation, we allowed the following thermoregulatory behaviors: changing its body orientation relative to direct insolation, moving along the specified interval of shade percentage, and climbing from 3 up to 120cm perch height. Each combination of levels of perch height, year, season, and polygon had a sample size of 150 records. We compared the vegetation cover in three months of the rainy season, and the microclimate temperature, TSM, foraging duration, and metabolic rate in three months of the dry season. Note: Data from a resubmitted research to be published in Journal of Thermal Biology.

Supplementary data

Recurrence occurs in up to 36% of patients treated with curative-intent radiotherapy for NSCLC. Identifying patients at higher risk of recurrence for more intensive surveillance may facilitate earlier introduction of the next line of treatment. We aimed to use radiotherapy planning CT scans to develop radiomic classification models that predict overall survival (OS), recurrence-free survival (RFS) and recurrence two years post-treatment for risk-stratification. A retrospective multi-centre study of >900 patients receiving curative-intent radiotherapy for stage I-III NSCLC was undertaken. Models using radiomic and/or clinical features were developed, compared with ten-fold cross-validation and an external test set, and benchmarked against TNM-stage. Such models could be integrated into the routine radiotherapy workflow, thus informing a personalised surveillance strategy at the point of treatment. Our work lays the foundations for future prospective clinical trials for quantitative personalised risk-stratification for surveillance following curative-intent radiotherapy for NSCLC. The radiomic feature data are provided here. Due to confidentiality, clinical data collected for the study are not publicly available for download, however the corresponding authors can be contacted for academic inquiries.

mt-SAF5 Leishmania infantum (strain JPCM5)

Municipal waste management cost

Test collection

Extended review and assessment of chloride-induced SCC are performed for stainless steel focusing on lower temperature in back-end fuel cycle. This practice further supports that the dominant parameter as (local) electrode potential for the SCC presented earlier. The data base collected and analyzed suggest that the SCC propagation rate is primarily related to dissolution rate, repassivation rate, aqueous-diffusion rate, and cracking rate. A simplified correlation of these parameters is presented to assess the observed crack growth rate. Other stress-related parameters (stress, stress intensification factor, strain rate) are also qualitatively assessed. The plasticity role (as in welding) is additionally discussed.

The dataset comprises GRACE-FO downscaled Total Water Storage Anomalies, at 0.1 degrees spatial resolution. Units are in mm with reference the 2004 - 2009 period. Abstract: A downscaling framework for coarse resolution Gravity Recovery and Climate Experiment (GRACE) Total Water Storage Anomaly (TWSA) data is described, exploiting the observations of precipitation from the Global Precipitation Measurement (GPM) mission, using the Integrated Multisatellite Retrievals for GPM (IMERG). Considering that the major driving force for changes in TWS is precipitation, we tested our hypothesis that coarse resolution, i.e., 1◦, GRACE TWSA can be effectively downscaled to 0.1◦ using GPM IMERG data. The algorithm for the downscaling process comprises the development of a regression equation at the coarse resolution between the GRACE and GPM IMERG data, which is then applied at the finer resolution with a subsequent residual correction procedure. An ensemble of GRACE data from three processing centers, i.e., GFZ, JPL and CSR, was used for the time period from June 2018 until March 2021. To verify our downscaling methodology, we applied it with GRACE data from 2005 to 2015, and we compared it against modeled TWSA from two independent datasets in the Thrace and Thessaly regions in Greece for the same period and found a high performance in all examined metrics. Our research indicates that the downscaled GRACE observations are comparable to the TWSA estimated with hydrological modeling, thus highlighting the potential of GRACE data to contribute to the improvement of hydrological model performance, especially in ungauged basins.

Uncropped Western blot images and immunostainings from Hunt et al.