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  • Image Dataset of Local Indonesian Soybean Seed Varieties (Anjasmoro, Grobogan, and DEGA-1)
    This dataset contains high-resolution scanned images of local Indonesian soybean seed varieties, namely Anjasmoro, Grobogan, and DEGA-1. The images were captured using a flatbed scanner under standardized conditions to ensure consistency in lighting, resolution, and background. Each seed was placed flat on the scanner glass to minimize distortion and maximize the visibility of morphological characteristics. The dataset includes both raw seed images and segmented seed images. The segmentation process was applied to isolate individual seeds from the background, allowing for more precise analysis of shape, size, color, and texture. These features are crucial indicators in assessing seed quality and potential productivity, and thus the dataset can serve as a valuable resource for research in seed science, plant breeding, and agricultural technology. Potential applications of this dataset include seed classification, variety identification, quality assessment, machine learning model training for automated seed recognition, and digital phenotyping studies. Researchers and practitioners in plant breeding and agricultural informatics may particularly benefit from this open dataset as it provides a benchmark for developing seed analysis methodologies.
  • NUTRICIA PROJECT
    This dataset contains all files generated through the activities of the NUTRICIA project (NUtritional Therapies for Recovery of Insulin-resistance-mediated Cognitive Impairment and Aging), conducted under the umbrella of the NUTRIBRAIN program, with financial support from the European Union. The dataset is publicly available in accordance with the FAIR principles for open science: FINDABLE: The dataset is assigned a persistent identifier (DOI) and is accompanied by rich metadata to support discovery. ACCESIBLE: The data and metadata can be accessed through a trusted repository, with clear usage licenses. INTEROPERABLE: The files are provided in standardized, widely used formats to facilitate integration with other resources. REUSABLE: The dataset includes detailed documentation on methods, variables, and provenance, enabling replication and further use in related research. All data are shared under the terms specified in the repository license, ensuring broad reuse and reproducibility.
  • misconduct
    misconduct
  • Experiências e desafios de cuidadores informais idosos de Pessoas com Deficiência
    O estudo “Experiências e Desafios de Cuidadores Informais Idosos de Pessoas com Deficiência” tem como objetivo analisar os desafios enfrentados por cuidadores informais idosos e como o envelhecimento influencia a dinâmica do cuidado. A pesquisa de campo utiliza a Escala Zarit de Sobrecarga do Cuidador para mensurar o desgaste físico, emocional, social e financeiro dos participantes. O protocolo de coleta de dados, com detalhamento das variáveis e instrumentos está anexado.
  • STIM1 and Endoplasmic Reticulum-Plasma Membrane Contact Sites Oscillate Independently of Calcium-Induced Calcium Release
    Calcium (Ca²⁺) release from intracellular stores, Ca²⁺ entry across the plasma membrane, and their coordination via store-operated Ca²⁺ entry (SOCE) are critical for receptor-activated Ca²⁺ oscillations. However, the precise mechanism of Ca²⁺ oscillations and whether their control loop resides at the plasma membrane or intracellularly remain unresolved. By examining the dynamics of stromal interaction molecule 1 (STIM1), an endoplasmic reticulum (ER)-localized Ca²⁺ sensor that activates the Orai1 channel on the plasma membrane for SOCE, in mast cells, we found that a significant proportion of cells exhibited STIM1 oscillations with the same periodicity as Ca²⁺ oscillations. These cortical oscillations, shared with ER-plasma membrane (ER-PM) contact sites proteins, were only detectable using total internal reflection fluorescence microscopy (TIRFM). Notably, STIM1 oscillations could occur independently of Ca²⁺ oscillations. Simultaneous imaging of cytoplasmic Ca²⁺ and ER Ca²⁺ with CEPIA1er revealed that receptor activation does not deplete ER Ca²⁺, whereas receptor activation without extracellular Ca²⁺ influx induces cyclic ER Ca²⁺ depletion. However, under such nonphysiological conditions, cyclic ER Ca²⁺ oscillations lead to sustained STIM1 recruitment, indicating that oscillatory Ca²⁺ release is neither necessary nor sufficient for STIM1 oscillations. Using optogenetic tools to manipulate ER-PM contact site dynamics, we found that persistent ER-PM contact sites reduced the amplitude of Ca²⁺ oscillations without alteration of oscillation frequency. Together, these findings suggest an active cortical mechanism governs the rapid dissociation of ER-PM contact sites, thereby control amplitude of oscillatory Ca²⁺ dynamics during receptor-induced Ca²⁺ oscillations.
  • Classification of coding and non-coding regions in eukaryotic gene sequences using an adaptive anti-notch filter designed using hybrid Salp Swarm-Whale algorithm incorporating a modified error function
    The repository contains all the nucleotide sequences and datasets used in the study in FASTA format.
  • A modified CSLE for slope-scale soil loss prediction under different vegetation types in China
    Vegetation can significantly reduce soil erosion by intercepting rainfall, reducing surface runoff, and improving soil properties. Increased vegetation coverage strengthens these effects by enhancing canopy density, root development, and litter accumulation. To quantify these effects, multiple coverage-based equations have been proposed for estimating vegetation-related factors in soil erosion prediction models such as the Universal Soil Loss Equation (USLE) and the Chinese Soil Loss Equation (CSLE). However, these equations often neglect understory vegetation, inadequately incorporate vegetation types, and rely on region-specific data, limiting their broader applicability across China’s diverse ecosystems. To address these limitations, this study developed three equations applicable nationwide for estimating the biological control factor (B) based on vegetation coverage for grassland, shrubland, and woodland. The method underwent calibration and validation using data from 54 sites, with further evaluation at 8 independent sites. Results revealed substantial enhancements in sediment yield prediction accuracy relative to the storm-based CSLE. During calibration, Nash-Sutcliffe Efficiency (NSE) values increased from 55.76% to 70.25% for grassland, from 44.08% to 81.95% for shrubland, and from -61.18% to 73.12% for woodland. Validation results exhibited parallel improvements, with NSE increasing from 61.07% to 74.55% for grassland, 48.44% to 77.41% for shrubland, and -77.00% to 68.23% for woodland. These findings collectively underscore the superior predictive performance and expanded geographical applicability of the proposed method across China's diverse ecosystems.
  • SYHX1901, an oral dual JAK/SYK inhibitor, for moderate-to-severe plaque psoriasis: a randomized phase 2 trial Journal of the American Academy of Dermatology
    This dataset includes supplementary materials for the Phase 2 clinical trial report on SYHX1901 for plaque psoriasis (JAAD)
  • Dataset for systematic review for art therapy in children with autism
    The study titled "Art Therapy Interventions and Developmental Outcomes in Children with Autism: A Systematic Review" does not explicitly state a research hypothesis as it is a systematic review of existing literature rather than an experimental study. However, the research questions guiding the review can be inferred as the basis for its exploration: (1) What are the current research patterns and future trends of art therapy for children with ASD over the past decade? (2) How do art therapy interventions influence developmental outcomes in children with ASD? The data presented in the study are derived from a systematic analysis of 22 articles published between 2016 and July 2025, retrieved from Web of Science, Scopus, and PubMed. The review identifies four primary themes: Emotional Expression and Regulation, Social Skills Development, Creative and Nonverbal Intervention, and Sensory and Relational Integration. These themes collectively highlight the multifaceted benefits of art therapy for children with ASD. Notable findings include the consistent enhancement of emotional recognition, expression, and regulation abilities in children with ASD through art therapy. The review also underscores significant improvements in social skills such as joint attention, cooperation, and social confidence, along with a reduction in stereotyped and repetitive behaviors. Additionally, art therapy is shown to improve sensory integration and promote high-quality parent-child attachment. These effects are observed to be transferable across different contexts, including home, school, and community settings. The data are interpreted to suggest that art therapy, with its visual, multisensory, and relationally attuned modalities, is a highly effective intervention for children with ASD. The review posits that the success of art therapy lies in its ability to create a therapeutic environment that is both sensory-rich and relationally supportive. By engaging children in creative expression while fostering synchronous interactions and emotional attunement, art therapy facilitates the development of key social and emotional skills. The study concludes that art therapy is a valuable, humanized approach that addresses the diverse needs of children with ASD, offering a promising pathway for future intervention design and evidence-based practice.
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