Data for: Nanostructured lipid carriers containing ondansetron hydrochloride by cold high-pressure homogenization method: preparation, characterization, and pharmacokinetic evaluation

Published: 2 August 2019| Version 1 | DOI: 10.17632/229gz2s4sv.1
Contributors:
Van-An Duong,
Thi-Thao-Linh Nguyen,
Han-Joo Maeng,
Sang-Cheol Chi

Description

The data describe the preparation, optimization, characterization, and evaluation of nanostructured lipid carriers (NLCs) loaded with ondansetron hydrochloride (OSH), a water-soluble drug. A modified cold high-pressure homogenization method was used, and the pH-dependent solubility of OSH was exploited to obtain NLCs with the enhanced entrapment efficiency (EE). The optimized formulation exhibited the sustained-release characteristic of the drug in vitro. After single subcutaneous injection in rats, the optimized OSH-loaded NLCs could prolong the drug release until 96 h with an extended mean resident time and enhanced systemic exposure compared to the OSH solution.

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