African swine fever virus protein p72 promotes NLRP3 inflammasome activation to induce pyroptosis
Published: 11 July 2024| Version 2 | DOI: 10.17632/254y7r4t96.2
Contributors:
xiaomin yuan, Min Huang, Simeng Feng, Huan Xie, Jiahao Cheng, Binghan Bai, Maokun Zhu, Lixin Wen, Bin Li, Wei DongDescription
Fig. 1 Transcriptomic analysis of ASFV p72 protein in 3D4/21 cells Fig. 2 GO and KEGG analysis and validation of DEGs. Fig. 3 ASFV p72 protein promotes the NLRP3 inflammasome to induce IL-1β secretion and pyroptosis. Fig. 4 ASFV p72 protein directly interacts with NLRP3 through its PYD domain. Fig. 5 The crucial amino acid residue for the function of p72 protein. Fig. 6 Schematic model: ASFV p72 induces NLRP3 inflammasome activation and pyroptosis.
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Institutions
Hunan Agricultural University
Categories
Viral Pathogenesis, RNA Sequencing, Immune Response, Host-Pathogen Interaction