A Comprehensive Endocrine and Clinical Dataset of 241 Women with Amenorrhea and Delayed Menstruation in the Kurdistan Region of Iraq
Description
Description This dataset provides a comprehensive endocrine and clinical profile of 241 women from the Kurdistan Region of Iraq, presenting with amenorrhea or delayed menstruation. The study was conducted between February 2025 and May 2026 to investigate the hormonal origins and clinical features of these conditions. Key features of the dataset include: • Study Population: 241 participants (married and single) aged 15 to 48 years. • Hormonal Parameters: Measurements of Prolactin, FSH, LH, AMH, TSH, T4, Testosterone, and Estradiol, acquired using the Cobas e 411 automated immunoassay analyzer. • Diagnostic Tools: A multimodal approach incorporating biochemical screening, ultrasonography (U/S), and magnetic resonance imaging (MRI). • Etiologies Covered: The data categorizes primary causes including Polycystic Ovary Syndrome (PCOS), Hyperprolactinemia, Ovarian Insufficiency, Thyroid Dysfunction, Diminished Ovarian Reserve (Low AMH), Hypoestrogenism, and Low Testosterone. • Clinical Indicators: Documentation of symptoms such as galactorrhea, vasomotor symptoms (hot flushes), and dermatological signs (hirsutism, acne). Potential Use: Researchers and clinical practitioners can utilize this dataset to identify correlations between hormonal imbalances and clinical symptoms, investigate metabolic aspects of reproductive disorders, and establish diagnostic benchmarks for the region.
Files
Steps to reproduce
The dataset was generated following these methodological steps: 1. Study Population & Clinical Assessment: 241 female patients (ages 15–48) presenting with amenorrhea or delayed menstruation (2 to 18+ months) were recruited at endocrine and gynecology clinics in the Kurdistan Region, Iraq. Clinical history, weight, and age were recorded. 2. Sample Collection: Venous blood samples were collected using serum separator tubes (SSTs) with a gel barrier. 3. Sample Processing: Samples were allowed to clot naturally, then centrifuged at 3,000 g for 10 minutes to separate the serum. Isolated serum was aliquoted and stored at -80°C until analysis to ensure analyte integrity. 4. Biochemical Analysis: Hormonal parameters (Prolactin, FSH, LH, AMH, TSH, T4, Testosterone, and Estradiol) were measured using the Cobas e 411 automated immunoassay analyzer (Roche Diagnostics) following the manufacturer’s protocols. 5. Diagnostic Imaging: In relevant cases, ultrasonography (U/S) and magnetic resonance imaging (MRI) were performed to confirm conditions such as PCO morphology, pituitary microadenomas, or thyroid issues. 6. Data Categorization: Patients were classified into endocrine etiology groups based on specific biomarker thresholds (e.g., FSH >40 mIU/mL for Ovarian Insufficiency, LH/FSH ratio >2 for PCOS).
Institutions
- Koya UniversityErbil, Erbil