Cross-system transcriptomic discordance in doxorubicin cardiotoxicity: Supplementary data and reproducibility package

Description

Supplementary data and reproducibility materials accompanying the manuscript “Cross-system transcriptomic discordance in doxorubicin cardiotoxicity: Prespecified four-cohort discovery and an acute adult human myocardial-slice challenge”. This deposit contains the version 18 supplementary and reproducibility package, including analysis scripts, derived results, supplementary tables, figures, source-data documentation, and file-integrity manifests. The study investigates cross-system transcriptomic responses to doxorubicin using publicly available gene-expression datasets. Original datasets are identified by their accession numbers in the manuscript and package documentation. This deposit provides derived research outputs and supporting computational materials; it does not constitute a new deposition of the original raw sequencing reads. The package documentation distinguishes preserved analysis outputs from subsequent verification and recalibration materials. Please consult README_v18 and the accompanying provenance and verification records before reuse.

Steps to reproduce

Download and extract the version 18 supplementary and reproducibility archive. Read README_v18 and the accompanying provenance documentation before running any scripts. Verify file integrity using the supplied manifests and verification utility. Consult the source-data manifest for the original dataset accession numbers and input sources. Follow the instructions provided for each analysis, including its required inputs and software dependencies. Preserved analysis outputs and subsequent verification or recalibration materials are identified separately in the package documentation.

Institutions

• University of Kufa

  An Najaf, Najaf

Categories

Licence