Fish oil data base

Published: 29 September 2026| Version 1 | DOI: 10.17632/2f422mkcyv.1
Contributors:
penghong guo, mengting xiao, Huimin Liu, Huimin Wang, Jiaxue Tian, Wenlu Xu, Xuemei Qin, xiaojie liu

Description

This study aims to elucidate the mechanism of anti-depressant effects of fish oil from the perspective of glycolipid metabolism homeostasis, with a focus on its underlying mechanisms involving PI3K-AKT signaling pathway. This study used a chronic unpredictable mild stress (CUMS)-induced rat model to explore fish oil's antidepressant effects. Behavioral tests showed significant improvement in depressive symptoms. Fish oil also reversed gut dysbiosis, enhancing microbiota diversity and abundance, such as Lactobacillus and UBA3282. Mechanistically, fish oil activated phosphatidylinositol 3-kinases (PI3K) / protein kinase B (AKT) signaling pathway, which contributed to the improvement in glycolipid metabolism. In addition, fish oil significantly increased glucose transporters and adenosine triphosphate (ATP) levels, while decreasing malondialdehyde (MDA) levels, showing that it reduced oxidative stress and enhanced energy metabolism of brain. These findings underscore fish oil's potential as a promising treatment for depression by targeting glycolipid metabolism.

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Fish Oil, Oxidative Stress, PI3K/AKT Pathway

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