40S Ribosome Remodeling Triggers 18S rRNA U-tailing and DIS3L2-dependent Decay

Name: 40S Ribosome Remodeling Triggers 18S rRNA U-tailing and DIS3L2-dependent Decay
Creator: Akruti Shah
Published: 2026-09-10T23:58:47.016Z
Keywords: Western Blot

Shah, Akruti; Coria, Aaztli; Miller, Jennifer; Orgebin, Emilien; Guiblet, Wilfried; Yang, Acong; Gu, Shuo; Wu, Colin Chih-Chien

doi:10.17632/2k3dykry2k.1

40S Ribosome Remodeling Triggers 18S rRNA U-tailing and DIS3L2-dependent Decay

Published: 10 September 2026| Version 1 | DOI: 10.17632/2k3dykry2k.1

Contributors:

Akruti Shah, Aaztli Coria, Jennifer Miller, Emilien Orgebin, Wilfried Guiblet, Acong Yang, Shuo Gu, Colin Chih-Chien Wu

Description

Our findings define a stepwise mechanism in which ribosome remodeling and RNA tailing commit defective 40S subunits to elimination, establishing a mechanistic framework for ribosome surveillance in mammalian cells.

40S Ribosome Remodeling Triggers 18S rRNA U-tailing and DIS3L2-dependent Decay

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