KCEM1 Paper Doyle-Roth Sept 2025
Published: 17 September 2025| Version 1 | DOI: 10.17632/2zwysv38zr.1
Contributor:
Robert DoyleDescription
Peptide synthesis data files. In vitro assay excel file of raw data. In vivo assay excel file of raw data.
Files
Steps to reproduce
Data was collected through use of microwave assisted peptides synthesizers, through use of high-throughput cAMP FRET based assays in stably transfected cells lines of target receptors, and in vivo in DIO rodents tracking body weight and glucoregulation (amongst other metrics) as primary phenotypes.
Institutions
- Seattle Children's Research InstituteWA, Seattle
- Syracuse UniversityNY, Syracuse
Categories
Drug Development, Pharmacodynamics, Peptides, Obesity, Melanocortin, Glucagon-Like Peptide-1 Receptor Agonist
Funders
- National Institutes of HealthMaryland, United States
- Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentMaryland, United StatesGrant ID: R21HD115119
- National Institute of Diabetes and Digestive and Kidney DiseasesMaryland, United StatesGrant ID: R01DK1135125
- National Institute of Diabetes and Digestive and Kidney DiseasesMaryland, United StatesGrant ID: R01DK135756