Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia

Published: 26 May 2023| Version 1 | DOI: 10.17632/3732f4z4jf.1
Contributors:
Lai Wenfang, Rui Luo, Yuheng Tang, Zhengshuang Yu, Binbin Zhou, Zelin Yang, John Brown, Guizhu Hong

Description

Background: Ischemic stroke still has few effective therapies and novel neuroprotective agents are attracting great interest. One of these, salidroside, a principal bioactive component of Rhodiola crenulata, extracts of which are used to treat stroke, exhibits neuroprotective properties across a remarkably wide time window in experimental stroke models. Purpose: To explore whether salidroside induces neurogenesis after cerebral ischemia and to identify its primary molecular target.

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Institutions

  • Fujian University of Traditional Chinese Medicine

Categories

Stem Cell

Funders

  • the Natural Science Foundation of Fujian Province, China
    Grant ID: 82174001
  • the Natural Science Foundation of Fujian Province, China
    Grant ID: 81973503
  • the Natural Science Foundation of Fujian Province, China
    Grant ID: 2021J02014
  • the Natural Science Foundation of Fujian Province, China
    Grant ID: 2020J01727
  • the Natural Science Foundation of Fujian Province, China
    Grant ID: 2019J01345

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