Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia

Name: Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia
Creator: Lai Wenfang
Published: 2023-05-26T05:07:27.498Z
Keywords: Stem Cell

Wenfang, Lai; Luo, Rui; Tang, Yuheng; Yu, Zhengshuang; Zhou, Binbin; Yang, Zelin; Brown, John; Hong, Guizhu

doi:10.17632/3732f4z4jf.1

Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia

Published: 26 May 2023| Version 1 | DOI: 10.17632/3732f4z4jf.1

Contributors:

Lai Wenfang, Rui Luo, Yuheng Tang, Zhengshuang Yu, Binbin Zhou, Zelin Yang, John Brown, Guizhu Hong

Description

Background: Ischemic stroke still has few effective therapies and novel neuroprotective agents are attracting great interest. One of these, salidroside, a principal bioactive component of Rhodiola crenulata, extracts of which are used to treat stroke, exhibits neuroprotective properties across a remarkably wide time window in experimental stroke models. Purpose: To explore whether salidroside induces neurogenesis after cerebral ischemia and to identify its primary molecular target.