Qi et al., WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
Published: 8 March 2022| Version 1 | DOI: 10.17632/37c32tjydg.1
Contributors:
Sixian Qi, Description
In this article, Qi et al. uncover a role of WWC family proteins in transducing signals from Hippo kinases to LATS1/2. Based on this mechanism, a SuperHippo minigene has been engineered to robustly and specifically activate LATS1/2, which in turn inhibit YAP/TAZ oncoproteins and tumorigenesis in multiple models.
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Institutions
Fudan University
Categories
Hippo Signaling Pathway