Catamenial Loss of Botulinum Toxin Efficacy Successfully Managed with Tamoxifen: A Case Report
Published: 22 June 2026| Version 1 | DOI: 10.17632/3h47mt9fzs.1
Contributors:
Simona Abou Tayeh, Cristelle Obeid, Georgio Chidiac, Nakhle AyoubDescription
Video 1: Baseline response to botulinum toxin type A (BoNT-A) injection before menses showing satisfactory aesthetic response with visible reduction in dynamic rhytids in the glabellar, frontal, and lateral canthal regions. Video 2: Reduced efficacy of BoNT-A during the perimenstrual phase demonstrating recurrence of dynamic rhytids and reduced neuromodulatory effect, temporally associated with the menstrual cycle. Video 3: Restoration of BoNT-A efficacy following initiation of tamoxifen demonstrating improved and sustained neuromodulatory response therapy at month 3 following her BoNT-A session.
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Categories
Botulinum Toxin, Estrogen, Tamoxifen