Angiomotin cleavage promotes leader formation and collective cell migration
Published: 6 August 2024| Version 1 | DOI: 10.17632/3nf9s7vgyc.1
Contributors:
, Description
Wang et al. demonstrate that the cleavage of AMOT is essential for collective cell migration and tumor metastasis. The cleavage of AMOT results in spatial redistribution from apical junctions to focal adhesions, promoting leader cell formation, cell fluidization, and coherent cell migration.
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Institutions
Fudan University
Categories
Cell Migration, Hippo Signaling Pathway