Short Term Overfeeding Disrupts Small Intestinal Barrier Integrity and Activates Hepatic Immunity in Healthy Men

Published: 14 September 2026| Version 1 | DOI: 10.17632/3s7y3847rm.1
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Description

Twenty healthy men underwent a 2-week hypercaloric diet (~4,600 kcal/day) combined with a sedentary lifestyle (<5,000 steps/day). Plasma biomarkers from a targeted Gastrointestinal Uptake and Translocation (GUT) panel, along with buffy coat 16S rRNA, were measured at baseline, post-intervention, and after 8 weeks of return to habitual lifestyle. The repository contains data from the plasma and buffy coat analyses related to the above mentioned manuscript.

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Inflammation, Overeating, Intestinal Mucosal Barrier, Plasma Biomarker

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