Physiologically based pharmacokinetic modelling facilitates prediction of clobetasol propionate skin permeation enhancement in vitro: a propylene glycol case study

Name: Physiologically based pharmacokinetic modelling facilitates prediction of clobetasol propionate skin permeation enhancement in vitro: a propylene glycol case study
Creator: Yuri Dancik
Published: 2026-09-28T11:04:42.045Z
Keywords: Skin, Pharmacokinetic Modeling, Dermal Drug Delivery

Dancik, Yuri; Tabosa, Alice; Thakur, Kanika; Zhang, Yanling; Rangappa, Srinath; Murthy, S Narasimha; Paterson, Daniel; Coleman, Lucy; Ghosh, Priyanka; Tsakalozou, Eleftheria; Polak, Sebastian; Clarke, James

doi:10.17632/3w88crwwnx.1

Physiologically based pharmacokinetic modelling facilitates prediction of clobetasol propionate skin permeation enhancement in vitro: a propylene glycol case study

Published: 28 September 2026| Version 1 | DOI: 10.17632/3w88crwwnx.1

Contributors:

,

Description

This dataset contains: 1) the experimental in vitro skin permeation and characterization data pertaining to the studied dermal formulations; 2) the Simcyp simulator V24 workspaces and associated datafiles used to simulate the in vitro skin permeation experiments. Abbreviations: CbP: Clobetasol Propionate IVPT: In Vitro Permeation Testing IVRT: In Vitro Release Testing PG: Propylene Glycol

Files

Funders

United States Food and Drug Administration
United States Department of Health and Human Services
Maryland, Silver Spring
Grant ID: U01FD007323

Physiologically based pharmacokinetic modelling facilitates prediction of clobetasol propionate skin permeation enhancement in vitro: a propylene glycol case study

Description

Files

Categories

Funders

Licence