Stability and biocompatibility  of hBD3 with different chiral configurations and their therapeutic efficacy in periodontitis

Name: Stability and biocompatibility of hBD3 with different chiral configurations and their therapeutic efficacy in periodontitis
Creator: Miaomiao Zhang
Published: 2025-10-27T14:53:40.234Z
Keywords: Microbiota

Zhang, Miaomiao; Can, Ni; Fuhua, Yan

doi:10.17632/3ystwvct9c.1

Stability and biocompatibility of hBD3 with different chiral configurations and their therapeutic efficacy in periodontitis

Published: 27 October 2025| Version 1 | DOI: 10.17632/3ystwvct9c.1

Contributors:

Miaomiao Zhang, Ni Can, Yan Fuhua

Description

We synthesized D-type human β-defensin 3 (D-hBD3), L-type human β-defensin 3 (L-hBD3), and natural recombinant human β-defensin 3 (r-hBD3), and applied different hBD3 and antibiotics in an experimental periodontitis mouse model. Changes in oral and intestinal flora were detected.

Stability and biocompatibility of hBD3 with different chiral configurations and their therapeutic efficacy in periodontitis

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