Chronic GVHD has similar or worse impact on skin-specific quality of life than autoimmune connective tissue diseases: a cross-sectional study

Description

Supplemental figures to support JAAD publication: Chronic GVHD has similar or worse impact on skin-specific quality of life than autoimmune connective tissue diseases: a cross-sectional study Supplemental figure 1. Sensitivity analysis of skin-specific quality of life in chronic graft-versus-host disease subtypes (epidermal, sclerotic, and combination) compared to dermatomyositis and cutaneous lupus erythematosus. Multivariate linear regression models adjusted for age, sex, and race demonstrate Skindex-29 scores were on average worse in epidermal and combination cGVHD compared to DM while there was no statistical difference for sclerotic cGVHD. This difference was clinically significant in total and subscale scores aside from the symptom subscale for combination disease. Skindex-29 scores were not statistically different in epidermal or combination cGVHD compared to CLE while total, symptom, and emotion scores were on average worse with clinically significant differences in CLE compared to sclerotic cGVHD. Point estimates have similar trends to primary analysis with wider confidence intervals due to smaller sample size per group. Supplemental figure 2. Sensitivity analysis of skin-specific quality of life in chronic graft-versus-host disease compared to dermatomyositis and cutaneous lupus erythematosus adjusting for clinical disease severity. Multivariate linear regression models comparing ssQoL in DM (n=332), CLE (n=85), and a subgroup of cGVHD in which clinical disease severity grading was available (n=35). When adjusting for disease severity, CLE had worse ssQOL in total score and emotion subscales in addition to the symptom subscale compared to cGVHD, which were clinically significant. Point estimates overall have similar trends to primary analysis with wider confidence intervals due to smaller sample size per group. Disease severity was measured by NIH Skin Score (0-3) with mild = 1, moderate/severe ≥2, Cutaneous Lupus Erythematosus Disease Area and Severity Index (0-100) with mild ≤14, moderate/severe > 14, and Cutaneous Lupus Erythematosus Disease Area and Severity Index (0-70) with mild ≤ 9, moderate/severe > 9.

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• University of Pennsylvania

  Pennsylvania, Philadelphia

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