SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditory cells
Published: 4 September 2025| Version 1 | DOI: 10.17632/46j777ndwf.1
Contributors:
Sung Il Cho, Eu-Ri Jo, Hee Sun JangDescription
Figure 1. Effects of SRT2104 on cell viability, SIRT1 activity, and senescence- and mitophagy-related protein expression in HEI-OC1 cells. Figure 2. Effects of SRT2104 on H₂O₂-induced cellular senescence and mitochondrial function. Figure 3. Effects of SRT2104 on the expression of senescence and mitophagy-related proteins in cochlear explants. Figure 4. Effects of SIRT1 knockdown on SRT2104-induced anti-senescent and mitophagy-promoting activities in HEI-OC1 cells.
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Institutions
- Chosun University College of Medicine
Categories
Cellular Senescence, Auditory System