Data for: The common carotid artery provides significant pressure wave dampening in the young adult sheep
The ‘Raw data including Figure 3 data James et al CCA’ dataset presents blood pressure measurements acquired in anaesthetised mature adult sheep, via pressure catheters placed in the common carotid arteries at proximal and distal positions, where the sheep were positioned in dorsal recumbency. The data includes diastolic pressure, systolic pressure and pulse pressure measured in 6 sheep on either the right or left sides; in one sheep both right and left sides were measured. Dp/dt max was determined for the proximal and distal pressure waveforms. Mean blood flow in the arteries was also reported. For flow, dp/dt max and pressure pulse analysis, the data from continuous runs of a minimum of 38 representative pressure waveforms were analysed automatically using RemLogic™ software. The ‘Summary Sheet’ presents the compiled data for each of the 7 studies, including the statistical determination of median and interquartile range for the mean values of flow, dp/dt max proximal, dp/dt max distal, proximal pressure pulse and distal pressure pulse from each study. Measurements of the lumen and wall thickness of the common carotid arteries were conducted using ultrasound on non-sedated animals prior to the study and are reported in the tab labelled ‘US lumen & wall thickness’. Tab ‘1’ presents the data for the first sheep, including the timestamp on the pressure pulse waveform, and the dp/dt max proximal, dp/dt max distal, diastolic pressure, systolic pressure and pulse pressure for each waveform analysed at proximal and distal positions. Proximal pressure pulse and distal pressure pulse are also presented. Average values for the study for dp/dt max proximal, dp/dt max distal, flow, proximal pulse pressure and distal pulse pressure are presented in columns K - O. Equivalent data for the second and subsequent sheep are presented in tabs ‘2’, ‘3a’, ‘3b’, ‘4’, and etc. Figure 3 presents two scatterplots derived from the Summary Sheet in this file, from the average proximal and distal pressure slope dp/dt max, and from the average proximal and distal pulse pressure values. The Figure 2 dataset presents representative data for blood pressure in the common carotid artery of the mature adult sheep from proximal and distal positions, including the timestamp for each of the measurements acquired at 250/s. The Figure 4 dataset presents pressure waveforms from catheters inserted into the common carotid artery of mature adult sheep to midway between pressure probe insertion points, with stepwise withdrawal of the catheters to different separation distances. It presents the timestamp for measurements acquired at 250/s, with the proximal and distal pressure measurements. For tab ‘a’ the pressure transducers are positioned at the midpoint between the pressure insertion points; for tab ‘b’ the transducers are separated by 9 cm; for tabs ‘c’, ‘d’ and ‘e’, the pressure transducers are at intermediate separations of 2 cm; 5 cm and 7 cm, respectively.