UDP-GlcUA triggers PKR kinase activity to promote liquid‒liquid phase separation of TOP2A and enhances radioimmunotherapy resistance.

Published: 1 October 2025| Version 2 | DOI: 10.17632/4hmk62xbcg.2
Contributors:
Hua Yu, Tiezhu Shi, Huiying Chu, Yufeng Ding, Guohui Li, Xiongjun Wang

Description

Uncropped western blots for figures appearing in Yu et al. Full details of methods and interpretation are provided in the associated manuscript.

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Steps to reproduce

Antibodies used for western blots are provided in the Key Resources table of the associated manuscript.

Institutions

  • Guangzhou University

Categories

Signal Transduction Pathway, Liquid-Liquid Phase Separation, Cancer Metabolism

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