Under Normoxia Simvastatin Shifts Lipid Metabolism of B16.F10 Melanoma Cells to Support Their Aggressiveness

Description

Supplementary data to paper: "Under Normoxia Simvastatin Shifts Lipid Metabolism of B16.F10 Melanoma Cells to Support Their Aggressiveness" by Negrea et al., 2024. These data represent: 1) the Supplementary Table corresponding to all the mRNA identified by RNA-seq in B16.F10 melanoma cells treated with lipophilic statin simvastatin (SIM), compared to the untreated cells. Our data revealed a panel of 1512 out of 15905 transcripts with at least 1.5 FR in expression after SIM treatment, with 816 transcripts upregulated, and 696 downregulated compared to the control group; 2) Figure 1. Validation of primer specificity by agarose electrophoresis of PCR products; 3) Figure 2. Relative expression of genes involved in metabolic pathways assessed by RT-qPCR; 4) Supplementary Table 2. GO and KEGG analysis results; 5) Supplementary Table 3. PPI data; 6) Supplementary Table 4. DEGs related to Aggresiveness.

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• L'Oréal - UNESCO “For Women in Science"

  Grant ID: Fellowship Programme no. 914, 2020 granted to dr. Alina Sesarman
• UEFISCDI grant

  Grant ID: PN-III-P2-2_1-PED-2021-0411, No. 659PED, 2022 granted to dr. Alina Sesarman

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