Mutations in the lacZ gene
Published: 21 November 2025| Version 2 | DOI: 10.17632/4n3bsmyskj.2
Contributors:
Matthew Meier, Marc Beal, Angela Dykes, Carole Yauk, Iain Lambert, Francesco MarchettiDescription
This is the raw data representing 6,465 independent lacZ mutations from multiple MutaMouse experiments. We curated lacZ mutations from published studies that were collected using a positive selection assay to identify mutations in lacZ that disrupted β-gal function. These 6,465 independent lacZ mutations cause in 2,732 missense mutations that impair β-gal function. The data were used in a publication on the functional mutational landscape of the lacZ gene.
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Steps to reproduce
Please see the code archived here: https://github.com/EHSRB-BSRSE-Bioinformatics/Beal_et_al_2023_lacZ
Categories
Genetics, Mutagenicity, Gene Mutation, Mutagenesis, Mutation, Mutation Rate, DNA Mutation, Mutagenesis Study, Mutagen Testing, Computational Biology