Capturing the Conversion of the Pathogenic Alpha-1 Antitrypsin Fold by ATF6 Enhanced Proteostasis

Published: 22 December 2022| Version 1 | DOI: 10.17632/4xyt372py7.1
Contributors:
Shuhong Sun, Chao Wang, Pei Zhao, Gabe M. Kline, Julia M.D. Grandjean, Xin Jiang, Richard Labaudiniere, R. Luke Wiseman, Jeffery W. Kelly, William E. Balch

Description

The excel file includes all the phenotype measurements for AAT variants with or without the treatment of AA-147 and AA-263. The folder includes the input source data, R-code scripts and output files for the phenotype landscapes, phenotype barcodes and functional structures in response to ATF6 activators.

Files

Institutions

Scripps Research Institute

Categories

Endoplasmic Reticulum, Machine Learning, Chaperone Protein, Protein Aggregation, Genetic Variation, Protein Misfolding, Endoplasmic Reticulum Stress, Protein Folding Disease, Gaussian Process

Funding

National Institutes of Health

HL141810

National Institutes of Health

HL095524

National Institutes of Health

AG049665

National Institutes of Health

AG070209

National Institutes of Health

DK123038

National Institutes of Health

AG046495

Licence