Software/Code for: CaV2.1 α1 subunit expression regulates presynaptic CaV2.1 abundance and synaptic strength at a central synapse

Published: 15 Jun 2019 | Version 3 | DOI: 10.17632/4ycrjtpfc6.3
Contributor(s):

Description of this data

contains custom-written functions used in "CaV2.1 α1 subunit expression regulates presynaptic CaV2.1 abundance and synaptic strength at a central synapse".

Experiment data files

Steps to reproduce

-calculates synaptic parameters by fitting synaptic currents from train stimulation to NpRf model.
Estimates N (RRP size), p (initial release probability), R (replenishment), and f (synaptic facilitation). This model was developed and described in "Thanawala MS, Regehr WG (2016) Determining Synaptic Parameters Using High-Frequency Activation. J Neurosci Methods 264:136–152." (http://dx.doi.org/10.1016/j.jneumeth.2016.02.021);

How to use:

Input:

  • EPSC/IPSC amplitudes from train stimulation, units are not important, but the estimated RRP will be in the same units

Output:

  • Struct containing estimated values for N, p, R, and f

To run call the function NpRfModel.m with an data vector containing EPSC/IPSC amplitudes during train stimulation.

When using, please cite the original publication:
"Thanawala MS, Regehr WG (2016) Determining Synaptic Parameters Using High-Frequency Activation. J Neurosci Methods 264:136–152." (http://dx.doi.org/10.1016/j.jneumeth.2016.02.021)

  • requires Optimization Toolbox and Curve Fitting Toolbox in Matlab (tm).

Related links

This data is associated with the following publication:

CaV2.1 α1 Subunit Expression Regulates Presynaptic CaV2.1 Abundance and Synaptic Strength at a Central Synapse

Published in: Neuron

Latest version

  • Version 3

    2019-06-15

    Published: 2019-06-15

    DOI: 10.17632/4ycrjtpfc6.3

    Cite this dataset

    Luebbert, Matthias; Goral, Rene Oliver; Keine, Christian; Thomas, Connan; Guerrero-Given, Debbie; Putzke, Travis; Satterfield, Rachel; Kamasawa, Naomi; Young, Jr., Samuel M. (2019), “Software/Code for: CaV2.1 α1 subunit expression regulates presynaptic CaV2.1 abundance and synaptic strength at a central synapse”, Mendeley Data, v3 http://dx.doi.org/10.17632/4ycrjtpfc6.3

Statistics

Views: 148
Downloads: 23

Previous versions

Compare to version

Institutions

University of Iowa, Max Planck Florida Institute, University of Iowa Roy J and Lucille A Carver College of Medicine

Categories

Software, Synaptic Vesicle Release, Synaptic Physiology, Calcium Channels, Calcium Channel Expression, Presynaptic Mechanisms of Synaptic Transmission

Licence

CC BY 4.0 Learn more

The files associated with this dataset are licensed under a Creative Commons Attribution 4.0 International licence.

What does this mean?

This dataset is licensed under a Creative Commons Attribution 4.0 International licence. What does this mean? You can share, copy and modify this dataset so long as you give appropriate credit, provide a link to the CC BY license, and indicate if changes were made, but you may not do so in a way that suggests the rights holder has endorsed you or your use of the dataset. Note that further permission may be required for any content within the dataset that is identified as belonging to a third party.

Report