Pancreatic adenocarcinoma treated with MEK, autophagy and immune checkpoint inhibitors reveals a responsive epithelial subtype within the heterogenous tumor that is enriched in murine models but not in humans

Published: 15 September 2026| Version 1 | DOI: 10.17632/52hc7f6shv.1
Contributors:
Aleksandar Obradovic, Brian Labadie, Alexander Raufi, Urszula Wasko, Lorenzo Tomassoni, Manan Vij, Liner Ge, Sarah Sta Ana, Michael May, Naomi Sender, Isabelle Ross, Linda Wu, Li Li, Sinan Abuzaid, Alina Iuga, Parin Shah, Alex Lyashchenko, Julia Wulfkuhle, WInston Wong, Ilenia Pellicciotta, Benjamin Izar, Emanuel Petricoin, Serge Cremers, Aik Choon Tan, Shing Lee, Andrea Califano, Kenneth Olive, Gulam Manji

Description

Single-Nucleus RNA-Seq Data from Pancreatic Cancer patients on clinical trial. Includes integrated gene expression seurat object with raw counts and scaled data as well as metadata annotations for each cell. Also includes integrated VIPER inferred protein activity object with metadata labels, and R script with code for survival analyses, frequency plots, and GSEA enrichment analyses. See manuscript methods for further detail.

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Categories

Pancreatic Cancer, Single-Cell RNA Sequencing

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