Transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional lung models

Published: 27 April 2022| Version 1 | DOI: 10.17632/58k4dh2prp.1
Contributors:
Thomas Caracena, Rachel Blomberg, Rukshika Hewawasam, David Riches, Chelsea Magin

Description

This dataset contains results of studies conducted within 3D, biomaterial-based lung tissue models that show transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional lung models. Material characterization and results of cellular responses including live/dead stains, image analysis for fibrotic activation markers, and qRT-PCR for gene epxression are included.

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Institutions

  • University of Colorado Denver

Categories

Biomaterials, Lung, Fibrosis

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