Final Analysis Dataset: Effects of a Sound-Based Meditative Intervention on Anxiety, Depression, Salivary Cortisol, and Blood Pressure

Description

This repository contains the corrected, de-identified final analysis dataset for the randomized controlled trial titled “Effects of a Sound-Based Meditative Intervention on Anxiety, Depression, Salivary Cortisol, and Blood Pressure.” The dataset includes 100 participants allocated to intervention and control groups, with age, gender, baseline and post-intervention Hospital Anxiety and Depression Scale-Anxiety (HADS-A) and Hospital Anxiety and Depression Scale-Depression (HADS-D) scores, salivary cortisol levels, systolic blood pressure, and diastolic blood pressure. Change scores are calculated as post-intervention values minus baseline values. The dataset supports the revised manuscript analyses, including baseline comparisons, descriptive within-group changes, and baseline-adjusted between-group ANCOVA analyses. HADS-A is the primary analysis reported in the manuscript; HADS-D, salivary cortisol, and systolic blood pressure are secondary outcomes, while diastolic blood pressure is reported as an exploratory physiological outcome. This repository supersedes the prior related dataset deposited at DOI: 10.17632/ts5sbcxgv9.3. The earlier dataset remains part of the public record and should not be used for the analyses reported in the revised manuscript.

Steps to reproduce

Download sound trial Participant_Data -final.csv, HADS_Item_Scores_FINAL.xlsx, and UNS_28_Day_Attendance_FINAL.xlsx. The CSV is the de-identified final analysis dataset and contains 100 participants: 50 Control and 50 Intervention participants. It includes participant ID, group, age, gender, baseline and post-intervention HADS-A, HADS-D, salivary cortisol, systolic blood pressure, and diastolic blood pressure values. Use Python version 3.12.13 with pandas 2.2.3, SciPy 1.17.0, and NumPy 2.3.5. Confirm that every participant has a unique participant ID, group assignment, and complete baseline and post-intervention outcome values. Use HADS_Item_Scores_FINAL.xlsx to verify HADS scoring. HADS-A and HADS-D each contain seven items scored from 0 to 3. Confirm that each subscale total equals the sum of its seven items and ranges from 0 to 21. Use UNS_28_Day_Attendance_FINAL.xlsx to summarize scheduled-session attendance over 28 days and intervention-group home-practice completion. Calculate change scores as post-intervention value minus baseline value; negative values indicate reductions from baseline. Reproduce baseline characteristics using independent-samples t-tests for continuous variables and Pearson’s chi-square test for sex distribution. Calculate baseline mean, post-intervention mean, and mean change for descriptive within-group results. For the primary between-group analysis, fit ANCOVA models with post-intervention outcome as the dependent variable, study group as the independent variable, and the corresponding baseline value as a covariate. HADS-A is the primary outcome reported in the manuscript. HADS-D, salivary cortisol, and systolic blood pressure are secondary outcomes. Diastolic blood pressure is exploratory. For each model, report the adjusted Intervention-versus-Control difference, 95% confidence interval, t statistic, two-sided p-value, and partial eta squared. Apply the Holm procedure across the five reported outcomes. Compare the reproduced outputs with Tables 1–4 and the Results section of the revised manuscript.

Institutions

• Medical University Pleven

  Pleven, Pleven

Categories

Funders

• UNS RESEARCH COUNCIL

  Grant ID: UNS/FEQ/2024

Licence