Anti-PD-1 immunotherapy with ADT induces robust immune infiltration in Metastatic Castration-Sensitive Prostate Cancer

Published: 28 October 2023| Version 1 | DOI: 10.17632/5nnw8xrh5m.1
Contributors:
Jessica Hawley, Aleksandar Obradovic, Matthew Dallos, Emerson Lim, Karie Runcie, Casey Ager, James McKiernan, Christopher Anderson, Guarionex Decastro, Joshua Weintraub, Renu Virk, Israel Lowy, Jianhua Hu, Matthew Chaimowitz, Xinzheng Guo, Ya Zhang, Michael Haffner, Jeremy Worley, Mark Stein, Andrea Califano, Charles Drake

Description

Data associated with manuscript "Anti-PD-1 immunotherapy with ADT induces robust immune infiltration in Metastatic Castration-Sensitive Prostate Cancer" -- includes .rds format Seurat object of gene expression matrix, with patient ID, treatment, timepoint, and cluster metadata, as well a Seurat object of inferred VIPER protein activity, with the same metadata annotations. Code used to perform all analyses is included, as well as folder containing ARACNe gene regulatory network files used for VIPER inference.

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Categories

Prostate Cancer, Immunotherapy, Single-Cell RNA Sequencing, Tumor Immune Microenvironment

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