The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers

Published: 10 Nov 2018 | Version 1 | DOI: 10.17632/5tk7md7rxz.1
Contributor(s):

Description of this data

The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers.
High-risk Human Papilloma Viruses (HPV) cause cervical, anal and oropharyngeal cancers, unlike the low-risk HPVs, which cause benign lesions. E6 oncoproteins from the high-risk strains are essential for cell proliferation and transformation in HPV induced cancers. We report that a cellular deubiquitinase, USP46 is selectively recruited by the E6 of high-risk, but not low-risk, HPV to deubiqutinate and stabilize Cdt2/DTL. Stabilization of Cdt2, a component of the CRL4Cdt2 E3 ubiquitin ligase, limits the level of Set8, an epigenetic writer, and promotes cell-proliferation. USP46 is essential for the proliferation of HPV-transformed cells, but not of cells without HPV. Cdt2 is elevated in human cervical cancers and knockdown of USP46 inhibits HPV-transformed tumor growth in xenografts. Recruitment of a cellular deubiquitinase to stabilize key cellular proteins is an important activity of oncogenic E6, and the importance of E6-USP46-Cdt2-Set8 pathway in HPV-induced cancers makes USP46 a target for the therapy of such cancers.

Experiment data files

This data is associated with the following publication:

The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers

Published in: Molecular Cell

Latest version

  • Version 1

    2018-11-10

    Published: 2018-11-10

    DOI: 10.17632/5tk7md7rxz.1

    Cite this dataset

    kiran, Shashi; Dar, Ashraf ; Singh, Samrendra Kumar ; Lee, Kyung Yong; Dutta, Anindya (2018), “The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers”, Mendeley Data, v1 http://dx.doi.org/10.17632/5tk7md7rxz.1

Statistics

Views: 68
Downloads: 34

Categories

Cervical Cancer, Human Papillomavirus

Licence

CC BY 4.0 Learn more

The files associated with this dataset are licensed under a Creative Commons Attribution 4.0 International licence.

What does this mean?

This dataset is licensed under a Creative Commons Attribution 4.0 International licence. What does this mean? You can share, copy and modify this dataset so long as you give appropriate credit, provide a link to the CC BY license, and indicate if changes were made, but you may not do so in a way that suggests the rights holder has endorsed you or your use of the dataset. Note that further permission may be required for any content within the dataset that is identified as belonging to a third party.

Report