Data for: Interleukin-21 enhances the antibody avidity elicited by DNA prime and MVA boost vaccine

Published: 23 Aug 2019 | Version 1 | DOI: 10.17632/5w9bdd2h4z.1
Contributor(s):

Description of this data

Enhancement of the magnitude or affinity of protective antibodies (Abs) induced by vaccine adjuvant is highly desirable to prevent challenging pathogens such as HIV-1. IL-21 plays a crucial role in germinal center reactions during humoral immune responses. However, the effect of IL-21 as a vaccine adjuvant on the quantity and quality of antigen-specific Abs elicited by DNA prime and MVA boost vaccine, a commonly used vaccine strategy, remains unknown. To close this knowledge gap, female adult B6N mice were primed with DNA vaccine twice (days 0, 14, 100 µg, I.M.) and boosted with MVA vaccine (day 28, 2 ×107 pfu, I.M.) with or without IL-21 DNA adjuvant (days 3, 17, 31, 40 µg, I.M.), in which HIV-1 gag was expressed as a model antigen. With the addition of IL-21 adjuvant, we found significantly increased avidity of antigen-specific Abs at multiple time points in longitudinal follow up. Collectively, our results suggest that IL-21 immune adjuvant can significantly increase Ab quality induced by heterologous DNA-MVA prime-boost vaccine strategy.

Experiment data files

This data is associated with the following publication:

Interleukin-21 enhances the antibody avidity elicited by DNA prime and MVA boost vaccine

Published in: Cytokine

Latest version

  • Version 1

    2019-08-23

    Published: 2019-08-23

    DOI: 10.17632/5w9bdd2h4z.1

    Cite this dataset

    Li, Qingsheng (2019), “Data for: Interleukin-21 enhances the antibody avidity elicited by DNA prime and MVA boost vaccine”, Mendeley Data, v1 http://dx.doi.org/10.17632/5w9bdd2h4z.1

Statistics

Views: 51
Downloads: 10

Categories

Adjuvant, Vaccination

Licence

CC BY 4.0 Learn more

The files associated with this dataset are licensed under a Creative Commons Attribution 4.0 International licence.

What does this mean?

You can share, copy and modify this dataset so long as you give appropriate credit, provide a link to the CC BY license, and indicate if changes were made, but you may not do so in a way that suggests the rights holder has endorsed you or your use of the dataset. Note that further permission may be required for any content within the dataset that is identified as belonging to a third party.

Report