mTOR lactylation acts to promote autophagy in skeletal muscle

Published: 16 May 2022| Version 1 | DOI: 10.17632/62956883b6.1
Contributors:
Yan Li,
,
,

Description

Mice with a defect in mTOR lactylation in muscle due to the loss of LDHA exhibit impaired autophagy and cannot maintain normal muscle weight and function. Elevated mTOR K921 lactylation during aging in muscle may play a protective role against autophagic dysfunction-associated myopathy.

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Institutions

Jiangnan University School of Food Science and Technology

Categories

Mammalian Target of Rapamycin, Skeletal Muscle

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