mTOR lactylation acts to promote autophagy in skeletal muscle
Published: 16 May 2022| Version 1 | DOI: 10.17632/62956883b6.1
Contributors:
Yan Li, , , Description
Mice with a defect in mTOR lactylation in muscle due to the loss of LDHA exhibit impaired autophagy and cannot maintain normal muscle weight and function. Elevated mTOR K921 lactylation during aging in muscle may play a protective role against autophagic dysfunction-associated myopathy.
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Institutions
Jiangnan University School of Food Science and Technology
Categories
Mammalian Target of Rapamycin, Skeletal Muscle