SAXS curve of human ferritin pathogenic mutant LN2 (DNA mutation c.497_498dupTC, causing the amino acid change p.Phe167SerfsX26) with 50 Iron/protein shell

Published: 19 May 2025| Version 1 | DOI: 10.17632/6f4rnttcnw.1
Contributor:
Flavio Di Pisa

Description

SAXS curve of human ferritin mutant LN2, associated with the neurodegenerative disorder neuroferritinopathy (MeSH term: C548080; Orphanet classification: Disorder; ICD-11 code: 8A01.1Y – chorea due to neuroferritinopathy), loaded with 50 Iron/protein shell, corresponding to 3 Iron/Ferritin monomer.

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Steps to reproduce

The purified protein was subjected to SAXS analysis to determine the amount of iron that can be stored inside the protein nanocage before it loses its quaternary assembly. This dataset refers to the protein loaded with 50 Iron ions per protein cage (24 subunit).

Institutions

  • Istituto di Biofisica Consiglio Nazionale delle Ricerche Sede secondaria di Milano
    Lombardia, Milano

Categories

Neurodegenerative Disorder

Funders

  • European Union - Next Generation EU - PNRR, MUR code IR0000011, CUP B51E22000150006, project ‘EBRAINS-Italy

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