Bile Acids Are Endogenous Antagonists For the Leukemia inhibitory factor (LIF) receptor

Name: Bile Acids Are Endogenous Antagonists For the Leukemia inhibitory factor (LIF) receptor
Creator: Cristina Di Giorgio
Published: 2023-09-26T14:17:22.739Z
Keywords: Stomach Cancer, Bile Acid, Receptor

Di Giorgio, Cristina; Fiorucci, Stefano; marchianò, silvia; Biagioli, Michele

doi:10.17632/7j7vm89d96.1

Bile Acids Are Endogenous Antagonists For the Leukemia inhibitory factor (LIF) receptor

Published: 26 September 2023| Version 1 | DOI: 10.17632/7j7vm89d96.1

Contributors:

Cristina Di Giorgio, Stefano Fiorucci, silvia marchianò, Michele Biagioli

Description

The leukemia inhibitory factor (LIF) receptor is involved in various cellular processes, including gastrointestinal cancer growth and invasiveness. Secondary bile acids such as DCA, LCA and its derivatives were found to inhibit LIF/LIFR complex formation, and STAT3 phosphorylation.

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Universita degli Studi di Perugia

Bile Acids Are Endogenous Antagonists For the Leukemia inhibitory factor (LIF) receptor

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