Bile Acids Are Endogenous Antagonists For the Leukemia inhibitory factor (LIF) receptor

Published: 26 September 2023| Version 1 | DOI: 10.17632/7j7vm89d96.1
Contributors:
Cristina Di Giorgio, Stefano Fiorucci, silvia marchianò, Michele Biagioli

Description

The leukemia inhibitory factor (LIF) receptor is involved in various cellular processes, including gastrointestinal cancer growth and invasiveness. Secondary bile acids such as DCA, LCA and its derivatives were found to inhibit LIF/LIFR complex formation, and STAT3 phosphorylation.

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Institutions

Universita degli Studi di Perugia

Categories

Stomach Cancer, Bile Acid, Receptor

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