Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells.

Published: 14 February 2025| Version 1 | DOI: 10.17632/7y2bm72bgm.1
Contributor:
yue yang

Description

Carvacrol (CAV) exhibits the capacity to augment endoplasmic reticulum autophagy (ER-phagy) in bovine mammary epithelial cells, mitigating endoplasmic reticulum stress (ER-stress) and inflammatory responses, thereby contributing positively to the amelioration of bovine mastitis. By Yang et al. In this paper, the effect of natural plant monomer CAV on enhancing ER-phagy and alleviating ER-stress and inflammation in mammary epithelial cells of dairy cows was discussed in the treatment of mastitis. Through in vivo and in vitro experiments, we found that ER-stress in mastitis tissue was significantly up-regulated, and the ER-phagy pathway, a key pathway that regulates cell homeostasis, was impaired. And CAV was proved to enhance endoplasmic reticulum autophagy. We found that there is a correlation between ER-phagy and ER-stress in dairy mammary epithelial cells, which may be an important direction for the treatment of dairy mastitis.

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Institutions

China Agricultural University

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Dairy Cattle

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