Cofilactin rod formation mediates inflammation-induced neurite degeneration.

Description

Uruk et al. demonstrate that the brain inflammatory response causes neurite (axon and dendrite) degeneration by a mechanism involving NOX2-induced cofilactin rod (CAR) formation. Neurites are more vulnerable to Inflammation-induced injury than neuronal cell bodies, and neurite loss in the absence of neuronal cell body loss is associated with functional impairment.

Institutions

• University of California San Francisco

  CA, San Francisco

Categories

Funders

• United States Department of Veterans Affairs

  District of Columbia, United States

  Grant ID: RAS-1IO1 BX004884
• National Institutes of Health

  Maryland, United States

  Grant ID: JRB-1R01AG044812

Licence