Cofilactin rod formation mediates inflammation-induced neurite degeneration.

Published: 4 March 2024| Version 1 | DOI: 10.17632/829ywfmvrn.1
Contributor:
Gökhan Uruk

Description

Uruk et al. demonstrate that the brain inflammatory response causes neurite (axon and dendrite) degeneration by a mechanism involving NOX2-induced cofilactin rod (CAR) formation. Neurites are more vulnerable to Inflammation-induced injury than neuronal cell bodies, and neurite loss in the absence of neuronal cell body loss is associated with functional impairment.

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Institutions

University of California San Francisco

Categories

Inflammation, Nerve Degeneration

Funding

United States Department of Veterans Affairs

RAS-1IO1 BX004884

National Institutes of Health

JRB-1R01AG044812

Licence