data of NDP-MSH Modulates MC1R-cAMP/PKA Signaling and Rescues LPS-Induced Neuroinflammation, Synaptic Deficits, and Depressive-Like Behaviors in Mice

Name: data of NDP-MSH Modulates MC1R-cAMP/PKA Signaling and Rescues LPS-Induced Neuroinflammation, Synaptic Deficits, and Depressive-Like Behaviors in Mice
Creator: zhiting gong
Published: 2026-07-08T16:51:28.372Z
Keywords: Untargeted Metabolomics

gong, zhiting; Qu, Shanglan; Peng, Xin; Ji, Jieyu; He, Ershu; Jiang, Le; Ma, Ruixue; Li, Hanwei; Li, Yanjiao; li, lijuan; Yow, Hui Yin; Hamzah, Sharina

doi:10.17632/8rsxrhfp68.1

data of NDP-MSH Modulates MC1R-cAMP/PKA Signaling and Rescues LPS-Induced Neuroinflammation, Synaptic Deficits, and Depressive-Like Behaviors in Mice

Published: 8 July 2026| Version 1 | DOI: 10.17632/8rsxrhfp68.1

Contributors:

,

, Ruixue Ma,

,

, Hui Yin Yow,

Description

To further elucidate the mechanisms by which NDP-MSH alleviates LPS-induced depressive-like behaviors, untargeted metabolomic profiling of the prefrontal cortex was performed across different treatment groups. The experimental groups included: saline (Ctrl, vehicle-treated mice), LP (mice injected with LPS), NDP (mice co- treated with LPS and NDP-MSH), LNH (mice co-treated with LPS, NDP-MSH, and the PKA inhibitor H89), and H (mice treated with H89 alone)

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Dali University
Yunnan, Dali

data of NDP-MSH Modulates MC1R-cAMP/PKA Signaling and Rescues LPS-Induced Neuroinflammation, Synaptic Deficits, and Depressive-Like Behaviors in Mice

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