Sex-biased enhancers shape transcriptional sex differences across human tissues
Description
This dataset accompanies the manuscript “Sex-biased enhancers shape transcriptional sex differences across human tissues”. Using the eModule computational framework, we identified 13,101 sex-biased active enhancers, 676 sex-biased super-enhancers, and >160,000 enhancer-mediated TF–target gene regulatory modules from GTEx v8 RNA-seq data across 41 adult human tissues. The dataset also includes primate-specific transposable element (TE)-derived enhancers, TF binding site enrichments, GWAS variant intersections, and drug-target regulatory links. Contents （1）Full lists of sex-biased enhancers, super-enhancers, and regulatory modules. （2）Primate-specific / TE-derived enhancer annotations and tissue-specific enrichments. （3）GWAS variant–enhancer intersections and sex-differential trait enrichments. （4）DrugBank therapeutic target genes regulated by sex-biased enhancers.
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Institutions
- Guangdong University of Petrochemical TechnologyGuangdong, Maoming