SUMO maintains the chromatin environment of human induced pluripotent stem cells
These files contain all raw data represented in the paper entitled SUMO maintains the chromatin environment of human induced pluripotent stem cells by Barbara Mojsa, Michael H. Tatham, Lindsay Davidson, Magda Liczmanska, Jane E. Wright, Nicola Wiechens, Marek Gierlinski, Tom Owen-Hughes and Ronald T. Hay. In this paper we show that in human induced pluripotent stem cells (hiPSC) SUMO modification is required to maintain the pluripotent state and plays an important role in organising the chromatin environment of these cells. In addition, we have for the first time investigated and described the landscape of protein SUMOylation in human stem cells, providing a number of new SUMO targets and sites suggesting a specific role for SUMO in these cells. We have also identified a novel target for SUMO-mediated transcriptional repression.