Thrombin is increased in diabetic retinal pathology in the STZ mice model, and its attenuation by a specific inhibitor, PARIN5, is associated with preserved function.
Published: 14 May 2026| Version 1 | DOI: 10.17632/8xzybwyd2z.1
Contributor:
zehavit goldbergDescription
This dataset contains the raw experimental data generated during the study investigating the role of thrombin/PAR1 signaling in early diabetic retinopathy using an STZ-induced diabetic mouse model and the potential protective effects of PARIN5 treatment. Data were collected from diabetic and non-diabetic C57BL/6J mice following induction of diabetes with streptozotocin (STZ). Experimental groups included untreated controls, STZ-treated animals (vehicle treatment), and STZ-treated animals receiving PARIN5 therapy. The dataset includes measurements obtained from biochemical assays, molecular analyses, immunofluorescence imaging, western blot quantification, and electroretinography (ERG) recordings.
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Institutions
- Tel Aviv UniversityTel Aviv, Tel Aviv
Categories
Biochemical Activity, Western Blot, Electroretinography